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5. Herpesviruses (12 credits)
Herpesviruses

Structure & classification, chemical composition, replication; concepts of primary infection, latency, reactivation and reinfection; modes of transmission and disease associations; HSV syndromes (genital, non-genital, ocular and CNS); neonatal infections, disseminated infections and illness in the immunocompromised host; VZV infections (primary disease, complications and recurrent illness), VZV in pregnancy and in the immunocompromised host; diagnosis (serology, culture and novel methods); treatment and prevention (vaccines & antivirals); Simian and other important "fast" herpesviruses (Inoue-Melnick virus).
CMV transmission and primary infections, latency, reactivation and reinfection, illness in the immunocompromised host; EBV transmission and primary infections, latency, reactivation, illness in the immunocompromised host, association with malignant disease; HHV-6 transmission and primary infections, latency & possible association of reactivation with illness, illness in the immunocompromised host; novel herpesviruses; diagnosis of herpesvirus infections (serology, culture and novel methods); treatment and prevention of herpesvirus infections (vaccines and antivirals); the ubiquitous nature of herpesviruses and their importance as pathogens of man and animals.

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