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Drug design, mechanisms
of action and evaluation; antivirals against Herpes group viruses
(Acyclovir, Famcyclovir, Gancyclovir); antivirals used in HIV
(Zidovudine, ddI, ddC); other antivirals (Amantidine, Ribavarin,
Foscarnet etc.); interferon, activity and mode of action; problems
of resistance and future prospects.
Vaccines (Live, attenuated vaccines, inactivated vaccines, sub-unit,
synthetic, recombinant and chaemeric vaccines); passive immunisation
and factors affecting vaccine efficiency; escape mutants, vaccine
breakthrough and vaccine failures; vector systems (baculoviruses
and vaccinia); the case against vaccination, future prospects.
Transformation, malignancy and metastasis; role of oncogenes;
interaction of environmental carcinogens and viruses; EBV and
Burkitt's lymphoma; Hepatitis B, Hepatitis C and liver cancer;
Papilloma virus and cervical cancer; Oncoviruses.
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